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Recently, a randomized trial compared this aggressive regimen with a more conservative transfusion regimen and found no differences in perioperative complications.
The authors and others have previously reported successful surgical outcomes using an aggressive erythrocyte transfusion regimen, designed to alleviate anemia and to reduce the percentage of sickle hemoglobin to below 30%.
METHODS: The authors therefore analyzed retrospectively their surgical experience in children with sickle hemoglobinopathies over the past 10 years to determine the efficacy of an aggressive transfusion regimen and skilled perioperative care in their patient population.
Other reasons for not adhering to a restrictive transfusion regimen may include the growing perception that transfusion trigger in the individual patient is too complex and important to be guided by a single Hb value alone [39, 40].
A restrictive transfusion regimen (Hb transfusion trigger less than 7.0 g/dl) resulted in fewer transfusions as compared with the liberal transfusion regimen (Hb transfusion trigger less than 10 g/dl) and appeared to be safe.
A restrictive transfusion regimen (Hb transfusion trigger <7.0 g/dl) resulted in fewer transfusions as compared with the liberal transfusion regimen (Hb transfusion trigger <10 g/dl) and appeared to be safe.
Similar(40)
Life-long transfusion regimens are essential to alleviate anaemia.
This hypothesis could be, probably, explained by testing the chitinases levels in less developed countries where transfusion regimens and chelation therapy are not readily available.
No prospective RCT has compared restrictive and liberal transfusion regimens in trauma, but 203 trauma patients from the Transfusion Requirements in Critical Care trial [ 228] were re-analysed [ 229].
No prospective randomised trial has compared restrictive and liberal transfusion regimens in trauma, but 203 trauma patients from the Transfusion Requirements in Critical Care (TRICC) trial [ 151] were re-analysed [ 118].
The incidence of multiple organ failure was higher in patients with more severe injuries, including TBI, than in patients without TBI (67%and71%1% versus 59%and56%6% according to the transfusion ratios, respectively), but did not differ when the transfusion regimens within the two subgroups were compared.
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