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Allogeneic red blood cell transfusion did not differ significantly among groups.
However, the clinical implications of these abnormalities are unclear since transfusion did not differ between cohorts.
The percentage of patients who had a transfusion did not differ by CKD stage, gender, age, baseline eGFR, Hb prior and closest to index date, comorbid conditions of diabetes, hypertension, cardiovascular disease, dyslipidemia, and cerebrovascular disease, or nephrology visit prior to anemia index date.
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The number of patients who received blood product transfusions did not differ significantly between the groups.
Minority races (African American and other races) had a higher unadjusted rate of transfusion than Whites but after controlling for other characteristics, the adjusted transfusion rate did not differ across racial groups.
ICU management and transfusion practice did not differ between patients of both groups.
In a subgroup analysis of patients with a severe TBI in the TRICC trial by McIntyre and colleagues [ 28], the restrictive (hemoglobin of 70 to 90 g/L) and liberal (hemoglobin of 100 to 120 g/L) transfusion strategies did not differ in 30-day mortality or length of stay.
The incidence of multiple organ failure was higher in patients with more severe injuries, including TBI, than in patients without TBI (67%and71%1% versus 59%and56%6% according to the transfusion ratios, respectively), but did not differ when the transfusion regimens within the two subgroups were compared.
The need for allogeneic blood transfusion during ICU stay did not differ between the heparin-treated group and the control group (44% vs. 47%, p = 0.3), nor the mean amount of red blood cells units transfused (0.9 ± 0.8 vs. 0.9 ± 1.0, p = 0.5).
In line with this hypothesis, some effects of transfusion were apparent already after restrictive transfusion, and this patient group did not differ in EuroSCORE and time on heart-lung machine compared to nontransfused controls.
This difference, however, is surprisingly not clinically significant, since the number of red blood cell transfusions and haematocrit levels did not differ.
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