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SeraSeal is a new hemostatic agent which might help to reduce transfusion amounts if used additionally to bone wax.
Craniosynostosis surgery is often associated with severe perioperative bleeding especially due to venae emissariae, resulting in large transfusion amounts of packed red blood cells (PRBCs).
Perioperative administration of celecoxib did not increase perioperative bleeding or blood transfusion amounts.
Age, base deficit, lactate, Glasgow Coma Score, and RBC transfusion amounts came from the medical record.
In reality, both of these adverse outcomes might not be linearly related to pRBC transfusion amounts, but could alternatively follow a threshold effect.
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However, after adjusting for the transfusion amount, the oldest age of transfused RBCs was not significantly related with the postoperative highest total bilirubin (r =0.06, P =0.056).
After adjusting for age and sex, multiple logistic regression analysis with variables including inotrope, tidal volume per PBW, transfusion amount, and volume of fluid revealed that only whether the patients required inotrope or not (OR 3.66, 95% CI 1.24 - 10.80, p = 0.019) influenced the results of respiratory complications.
We categorized transfusion amount as 5 or more, and 10 or more units of RBCs.
After adjusting for the transfusion amount, the oldest transfused RBCs showed a significant negative correlation with the postoperative base excess (r = -0.08, P =0.02).
On the other hand, the clinical adverse effects of storage time of RBCs disappeared after adjusting for confounding factors including transfusion amount, possibly due to RBCs breakdown that occurs during RBCs processing regardless of RBCs age [ 24].
Pearson's correlation or Spearman's rank correlation coefficients were used as appropriate to analyze the relationships between RBC transfusion amount and some continuous variables such as postoperative base excess, total bilirubin, length of ICU and hospital stay.
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