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In contrast, this transforming capability was dramatically reduced in cells expressing Bcr-Abl I164E.
Colonies were counted and transforming capability assessed after 21 days of growth.
This could explain why the transforming capability of Aurora A in human cells is detected mainly when the p53 pathway is compromised.
Characterisation of primary cultures PAP60 and MIH55 determined their highly proliferating advantage, transforming capability and tumorigenicity in vitro and in vivo.
Interestingly, the common trait behind their efficient cell transforming capability is their enhanced localization at the plasmalemma, achieved by a PHD with increased lipotropy (E40K mutation) or by the presence of a myristoylation signal, artificially introduced or provided by the viral Gag sequence fused to Akt in v-Akt (Aoki et al., 1998).
Even though both cell lines were highly tumorigenic, PAP60 did present a better transforming capability and elevated proliferation rate but was less able to migrate through Matrigel-coated filters and form tumours in SCID mice compared with the MIH55 cell line.
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Both PAP60 and MIH55 exhibited significant transforming capabilities with PAP60 having the greatest malignant transformation.
Startups across the world are transforming capabilities that were once relegated to specialty labs with large, expensive capital equipment and highly trained technicians.
When a new business model is implemented in a start-up or within an established firm, the organization's transforming capabilities come into play to configure, or reconfigure, the necessary resources and maintain organizational coherence.
These data underscore a clear role for HPV-16 E7 in enhancing cell survival and provide additional evidence for the transforming capabilities of the E7 oncoprotein from high-risk HPVs.
Life science and biotechnology advances have provided transforming capabilities that could be leveraged for InGBSV.
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