Abnormalities in the dopaminergic and noradrenergic systems might also be implicated but it remains unclear to what extent repeated trauma and abuse during childhood might modify the hypothalamic-pituitary-corticotropic axis in response to chronic stress and transform permanently the modulation of physiological and psychological reactions of these children to their perturbed environment.
Sign up for the best of VICE, deLinkred to your isbox daily.
As a result, Tahquitz turned crazy/evil, transforming himself permanently into a shape-shifting demon bent on terrorizing his own people.
The Internet, and with it the ability of campaigns to inexpensively reach millions of prospective donors, permanently transformed fundraising.
The hysterical fantasies written, drawn and painted of "The Indian Mutiny" permanently transformed British attitudes to India.
From 1865 to 1870, Congress passed, and the states ratified, the 13th, 14th and 15th Amendments, which permanently transformed the country.
The pastoral landscape surrounding the city had been permanently transformed, and nine villages Beaumont, Bezonvaux, Cumières, Douaumont, Fleury, Haumont, Louvemont, Ornes, and Vaux were entirely destroyed.
Critics and some environmental groups, while acknowledging improvements, say the oil quest always leaves scars, the innovations come with new risks, and -- most important -- once oil is found a wild landscape is permanently transformed.
And yet for all the Sturm und Drang, no biographer has shed any real light on how this small-town boy with no more than a grammar school education became the author of masterworks like "Hamlet," "Othello" and "King Lear," and in doing so permanently transformed the course of Western literature.
In his book, "They Call Me Assassin," published not long after the day he permanently transformed Stingley's life, Tatum wrote that he intended "an intimidating hit" on the play: "I like to believe," he wrote, "that my best hits border on felonious assault".
