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In NHL, the entire cancerous mass develops from a transformed lymphocyte.
In the case of lymphomas, a transformed lymphocyte in a secondary lymphoid tissue generates a solid mass.
In human, the first eQTL studies orginally focused on transformed lymphocyte cell lines (mainly the HapMap lymphoblastoid cell lines).
Vero or primary bovine kidney cells are usually used, but transformed lymphocyte lines are much more susceptible to rinderpest infection and should be used if routine isolations are being carried out, for example, Theileria-transformed bovine lymphocytes or transformed marmoset lymphoid cells (B95a).
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Like human CD30hi lymphomas, MD lymphomas are a heterogeneous mix of a minority of neoplastically transformed lymphocytes (CD30hi), surrounded by majority of non-transformed (CD30lo) lymphocytes [ 8, 9].
At high power field, a polymorphous population of small- to medium-sized lymphocytes, plasma cells, plasmacytoid cells, as well as large, basophilic transformed lymphocytes and immunoblasts diffusely infiltrated the paracortical area.
A biopsy specimen taken from a left inguinal lymph node showed distortion of the nodal architecture and polymorphous lymphoid infiltration containing many plasma cells and plasmacytoid cells with scattered transformed lymphocytes, as well as a large number of capillaries.
Maximal glycolytic enzyme activity levels are significantly reduced in transformed lymphocytes from the elderly though the number of transformed cells is also significantly reduced.
Up-regulation of telomerase appears important for the true immortalisation of transformed lymphocytes [65].
DNA and transformed lymphocytes were stored frozen in two different storage containers at two separate sites with continuous monitoring.
MD transformed lymphocytes have increased MDV oncogene "Meq" expression [ 19].
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