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Cell extracts ("ferments") that could effect chemical transformations were discovered, beginning with diastase in 1833.
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What is more, stripes characteristic for martensitic transformation were discovered in the β phase grains in all coatings.
The transformation was discovered on crystallographic spinel structures: the low-temperature (800 900 °C) tetragonal phase (t-CuFe2O4) and the high-temperature (∼1000 °C) cubic phase (c-CuFe2O4).
The handful of prototype reactions on which current bioorthogonal transformations are based were discovered long before the chemistry/biology interface was a fashionable venue for research.
Important fossils were discovered.
Many barriers to transformation have been discovered in other organisms, one principle being improper DNA methylation of the plasmids to be transformed.
While our belief in this kind of magic gradually wanes, we can begin to understand that there are more tangible magical transformations waiting to be discovered.
Although the increment of sialic acid in serum of cancer or inflammatory disease patients was reported from the 1950s, the fact that abnormal glycosylation patterns are observed in malignant transformation of cells was discovered in the late 1960s [ 2].
However, the different behavior in laser-induced transformations and surface morphology changes was discovered for As45S55 thin film (see Fig. 5, curve 2).
In this work, the plasmid-to-plasmid variability in transformation efficiency in C. thermocellum was discovered to be impacted by E. coli Dcm methylation of the plasmid DNA.
Indeed, a mutation in Polycomb, the founding member of the PcG, was discovered for its segmental transformations (Lewis, 1947).
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