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We note that although we have focused our discussion here upon transformations of endogenous and synthetic steroids, we believe concepts of conserved structure and conserved bioactivity apply more generally to other contaminant classes.
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The cytochromes P450 (CYPs) played an important role in the development of various cancers, since they involved in the metabolic transformation of numerous endogenous and exogenous compounds including carcinogens and anti-cancer drugs [ 1].
These meta-models may be identical in the case of endogenous transformation or different in the case of an exogenous transformation.
In previous studies, we demonstrated that alkynyl cholesterol (a-Chol) could be incorporated into Neuro2a cells and metabolized to the a-Chol fatty acid esters in a transformation identical to that of endogenous cholesterol.
All this provides increasing evidence for further endogenous transformations of chlorophyll catabolites in senescent plants, beyond the stage of the NCCs.
The availability of the complete plastid genome sequence may facilitate transformation efficiency by using the precise sequence of endogenous flanking sequences and regulatory elements in chloroplast transformation vectors.
MCF-7 does have copy number abnormalities, which shows that at some point in its transformation to cancer, it was capable of endogenous chromosomal amplification.
However, whether these A. baumannii strains are able to engage in natural transformation remains unknown, and the presence of endogenous transducing phages in A. baumannii has not been demonstrated yet.
Transgenic mice overexpressing HER-2 or mutant forms of HER-2 with capacity to malignant transformation of cells exhibit high levels of endogenous HER-1 or HER-3 compared to controls [ 33, 34], suggesting a concomitant overexpression of the HER family members.
These bacteria perform a multitude of endogenous functions from the transformation of bile acids, breakdown of insoluble fibers, to the production of specific vitamins and cofactors, >.
These observations provide evidence that AREG-mediated activation of endogenous EGFR is required for full transformation downstream of YAP.
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