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In summary, this pilot mapping experiment has used natural transformation to identify a genetic interval carrying natural variation that affects transformability itself.
According to the strategy, we focused on scaffold transformation to identify imidazo[1,2-b]pyridazine derivatives as potent inhibitors of p38 MAP kinase.
The number of components in the sample XANES spectra was determined using principal component analysis (PCA) of all sample spectra, followed by target transformation to identify the most likely components of the spectra from a model compound library.
In previous work, we utilized an inducible model of cellular transformation to identify transcriptional regulatory circuits important in oncogenesis [ 10, 11].
Second is the use of statistical techniques, including multiple regression analyses that we have applied to our own data and those previously published in the literature, using the Box-Cox transformation to identify optimal transformations to normality.
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We use the same threshold for the z-transformation to identify significant response levels.
Linear combinations of the eigensolution obtained with an estimate of the stiffness properties are taken by using unitary transformation matrices to identify the actual eigensolution.
On the basis of correlation theory, this paper explains a method called "Single Point Discrete Fourier Transformation (DFT)" to identify the unbalance.
This in vitro culture system can be used to elucidate changes in gene expression occurring enroute to malignant transformation and to identify molecular markers of cancer stem/progenitor cells.
Thus, the identification and characterization of genes associated with ErbB2 overexpression would be beneficial, in order to better define the molecular mechanisms involved in ErbB2-dependent transformation and to identify novel drug targets.
In this study, we used the hTERT-immortalized human mammary epithelial cell line HME16C to examine which Ras signaling pathways are sufficient for transformation and to identify transcriptional targets downstream of those pathways that might modulate this phenotype.
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