Exact(1)
Novel molecular subtypes of cancer (differing, for example, in mechanism of transformation, propensity to metastasize, and sensitivity to particular therapies) have been identified from such profiles [ 1].
Similar(59)
Since P, S and the OEI deviated from normality, they were first transformed: OEI using a logarithmic transformation and propensity and severity by taking their reciprocal values.
The transition of a cancer from a 'localized' tumor to a metastatic form requires the acquisition of several cellular transformations, including migratory propensity and invasiveness (Chaffer and Weinberg, 2011; Valastyan and Weinberg, 2011), and these transformations are strongly influenced by the surrounding normal, heterogeneous tissues.
From a biological point of view, our cohort is thus characterized by a highly ineffective erythropoiesis but with a relatively low propensity of transformation to more advanced MDS.
Myelodysplastic syndromes (MDS) are a group of common bone marrow disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and a propensity for transformation to acute myeloid leukemia (AML).
Myelodysplastic syndromes (MDS) encompass a group of hematopoietic stem cell malignancies characterized by ineffective hematopoiesis, peripheral cytopenias, and a propensity for transformation into acute myeloid leukemia (AML).
Transformation - Transforms the user.
The elastic constants, mechanical properties, and propensity of phase transformation of cerium phases are evaluated, which demonstrates the feasibility of predicting phase transformation of cerium by the current established MD model.
Enhanced propensity for shear transformation zone nucleation in the low moduli surface is explained in terms of reduced atomic connectivity arising from a reduction in local co-ordination number and a lowering of the shear modulus.
Although both horizontal cells and photoreceptors may have an intrinsic propensity for neoplastic transformation, due to their suggested inability to be cleared via apoptosis, it is possible that the presence of crosstalk and feedback regulatory loops between OTX2 and MYCN pathways may be one of the components that drives the tumorigenesis in cells with photoreceptor-like molecular signature.
Even the most common 'benign' salivary tumor, pleomorphic adenoma, has a propensity for malignant transformation and possible recurrence.
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