The single most disruptive transformation in our way of understanding human health and disease is that we now know that there can be no pathology or disease without an underlying biology.
But creating so contagious a virus in the lab presents terrible risks in itself that far outweigh the benefits of understanding a transformation that may never occur in nature.
Recently, reduced levels of the autolytic ∼38 kDa product of HtrA1 were found to correlate with neoplastic bladder tissue undergoing cancerous transformation, which indeed highlights the importance of understanding the functional maturation of HtrA1 and the potential prognostic value of the autolytic forms.
We are also fortunate to have a clear sense of opportunity: students come to us predominantly from disciplinary-based high school science/mathematics education programs (see important companion essay by Barbara Nagle [2013] about how this is changing), amplifying our potential for transformation to a more interdisciplinary way of understanding the natural and mathematical sciences.
Failure of understanding.
What had happened, rather, was a transformation of the understanding of what wealth was: it was "given a higher purpose", in his words, swept up into a new imagery of the church as the shepherd of the local congregation.
In suggesting that alcoholism was a chemical condition marked by irresistible craving, he anticipated the transformation of our understanding of addiction from a defect of character into a disease, and recognized the reason that it would remain, at best, an uneasy hybrid of the moral and the medical.
Thus, this work serves as basis for transformation of qualitative understanding of polyethylene fire behavior into systematic quantification, which can be generalized for other polymers and their composites.
With the rise of new technologies and the help of policies favouring RES (renewable energy sources) a transformation of our understanding of the energy system and its possibilities has encouraged dramatic changes in the World's energy landscape.
Obviously a transformation of public understanding of this issue and also a transformation of policy responses.
