Sentence examples for transformation of tissue from inspiring English sources

The second group, which represent activated forms of normal cellular genes1,4 9, has been detected by the ability of certain genes from animal and human tumours to induce focal transformation of tissue culture cells.

Activation of sonic hedgehog signaling seems to precede transformation of tissue stem cells to cancerous stem cells, with the Gli-1 transcription factor functioning as a mediator of environmental signals.

For instance, work on long- and short-lived sea urchins (Strongylocentrotus franciscanus, Lytechinus variegatus) has shown that telomere fragments are maintained throughout life, with maintained telomerase activity throughout developmental stages and in adult tissue without causing neoplastic transformation of tissue [42].

He hypothesized that cancerous transformation of tissue was a result of an injured respiration, or metabolism.

Previous work found that such ectopic proliferative cells lack A/B polarity [ 12] and such change is associated with oncogenic transformation of tissue [ 18].

We hypothesized that the diffuse reflectance intensity decreases during the transformation of tissue from healthy to dysplastic due to morphologic, cytologic and vascular changes associated with transformation.

However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated.

Histological and morphometric studies have shown that the transformation of granulation tissue into scar tissue usually takes place within the first 2 months of injury [52], However, the duration of this process may vary depending on the amount of damaged tissue.

The CK expression patterns in tissues are well-maintained even during the process of transformation of the tissue from normal to tumor tissue [ 25].

Since then, aberrant over-expression of COX has been consistently associated with malignant transformation of healthy tissue, proliferation and increased invasiveness of malignant tissue, and unfavorable clinical outcomes.

The method combines two in vitro processes, namely the production of meristematic tissue with a high competence for plant regeneration and the genetic transformation of this tissue, followed by selection of transformed regenerants (Fig. 1).