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The observations that Eef1a2 transcripts are expressed at increased levels in the majority of primary PCT but in a smaller proportion of primary MM indicate that the mechanisms governing aberrant expression and possible contributions to transformation of plasma cells are likely to differ between the species.
Multiple myeloma is a neoplastic disorder caused by malignant transformation of plasma cells.
81 It was shown that in MM, miRNAs contribute to the malignant transformation of plasma cells.
This co-clustering suggests that different pathways can be utilized to achieve a similar outcome, namely transformation of plasma cells.
Because of extreme outliers, logarithmic transformation of plasma CCN2 values was performed before presentation of data in the figures.
Plasma curve decay represents logarithmic transformation of plasma concentrations before, during and after surgery, presented in the Figure.
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Factors influencing the sintering and phase transformation of plasma-sprayed Gd2O3-stabilized ZrO2 are discussed.
A log-transformation of plasma D-dimer concentration had the best association with growth rate model parameters suggesting that differences in AAA growth were predominantly driven by patients with the highest plasma D-dimer concentrations.
Log10 transformation values of plasma CCN2 were used in linear regression analysis.
On log transformation of the plasma insulin values, log insulin correlated negatively with plasma tHcy (r=−0.47; P=0.02).
In multiple myeloma (MM) there is a malignant proliferation of monoclonal plasma cells, where multistep genetic and microenvironmental changes lead to the transformation of normal plasma cells into a malignant neoplasm.
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