Sentence examples for transformation of intestinal from inspiring English sources
In conclusion, we demonstrate that the two MAP kinase kinase isoforms MEK1 and MEK2 have similar transforming properties and that activation of either isoform is sufficient for full transformation of intestinal epithelial cells up to the metastatic stage.
Simmini, S. et al. Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nat.
Loss of the cell membrane protein E-cadherin is a critical event during Ras-mediated transformation of intestinal epithelial cells.
Pomerleau V, Landry M, Bernier J, Vachon PH, Saucier C. Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.
These data, together with those demonstrating decreased Src activity in fully differentiated enterocytes, suggest that down regulation of Src-related tyrosine kinases is important for differentiation, and/or deregulation of the kinases is important for growth and transformation of intestinal epithelial cells.
This case report highlights the imaging findings for malignant transformation of intestinal endometriosis.
These experiments therefore strongly suggest the normal stem cell as the cell of origin for neoplasia, and that transformation of the intestinal stem cell is a primary route to intestinal neoplasia.
In contrast, primary colon organoids required combinatorial Apc, p53, Kras(G12D) and Smad4 mutations for progressive transformation to invasive adenocarcinoma-like histology in vitro and tumorigenicity in vivo, recapitulating multi-hit models of colorectal cancer (CRC), as compared to the more promiscuous transformation of small intestinal organoids.
Malignant transformation of small intestinal endometriosis is very rare.
Only three cases of malignant transformation of small intestinal endometriosis have been reported previously.
A high turnover rate would allow quick restitution of the lost tissue due to damage; but on the other hand, high turnover rate would require the presence of more active stem cells around and more frequent cell divisions, increasing the susceptibility to genome duplication-induced mutations and the risk of carcinogenic transformation of the intestinal tissue.
