Sentence examples for transformation in normal from inspiring English sources

TGFβ mediates both tumor suppressing and tumor promoting activities by (1) repressing transformation in normal cells and (2) increasing aggressiveness of transformed cells through induction of epithelial-mesenchymal transition (EMT), which leads to increased invasion and metastases. 1 TGFβ regulates target gene expression through SMAD-dependent and SMAD-independent pathways.

Our previous study found induced myofibroblastic transformation and multipotent haematopoietic stem cell transformation in normal human keratocytes 24 hours after CXL [ 33].

The ability of these oncoproteins to cause malignant transformation in normal cells makes them logical targets for the development of novel therapies for HPV-related cancers.

Furthermore, we demonstrated that the FADD/JNK pathway is the downstream pathway of αNAC and that αNAC is required for oncogenic transformation in normal fibroblast cells.

Overall, these results demonstrate that oncogenic activation of Grb2- and Shc-dependent signaling pathways, such as those activated by Tpr-Met, is sufficient to induce an epithelial-mesenchymal morphological-like transformation in normal IECs.

The small mean increases in laminar pore parameters calculated after 3D transformation in normal eyes were due to the fact that the anterior laminar surface was relatively flat with a high radius of curvature (see Fig. 6).

Additionally, following suggestions of Huttenhower et al. (2006), PCC values were adjusted using Fisher transformation, resulting in normal distributions of PCC values irrespective of the dataset analysed, further allowing for cross-dataset comparisons.

To assess the tumor-specific molecular and biological activities of HDACi, we used a defined model of human cell transformation in which normal cells had been converted to transformed (tumorigenic) states through the sequential introduction of genes encoding the SV40 large T and small t antigens, hTERT and H-RASG12V.

After 3 weeks in culture, neither the 10A cont nor the 10A L2 cells proliferated in soft agar (Supplementary Figure 1), suggesting that LOXL2 expression alone cannot drive complete oncogenic transformation in the normal 10A cells.

In keeping with Eph over-expression being a priming event it is notable that EphA2 over-expression causes malignant transformation in a normal mammary epithelial cell line (MCF-10A) [ 19].

Our laboratory has developed an in vitro model of HPV16-mediated human cell transformation in which normal HKc transfected with HPV16 DNA, HKc/HPV16, progress towards malignancy through HKc/GFI and HKc/DR stages [ 16- 18].