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The various locations associated with malignant transformation implicated a wide-range of tumors representative of the anatomic locations [ 38].
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In those nine years, he underwent an extraordinary transformation, which implicated every line on his face.
These signaling and developmental pathways crosstalk to regulate stem cell transformation and implicate a role of miRNAs in hepatic stem cell deregulation and cancer development.
Failure of trophoblast invasion and spiral artery transformation has been implicated in the pathogenesis of conditions such as pre-eclampsia and intrauterine growth restriction.
Malignant transformation is further implicated via chronic inflammation itself, and/or alterations of tumor suppressor genes (such as tumor protein 53 [p53]) or proto-oncogenes (such as mutations of Kirsten ras oncogene homolog [K-ras]).
This is consistent with the involvement of the insula in sound-to-speech transformations, with an implicated role in the temporal resolution, sequencing, and feedback processes crucial for auditory and motor processing, and the monitoring and adjustment of expressive performance.
Of the fraction of induced and repressed transcripts that were common to the three fusion proteins, most are not known to be directly implicated in transformation, and it is possible that the three fusion proteins use distinct mechanisms to transform primary cells, resulting nevertheless in tumors with an indistinguishable phenotype as assessed by conventional histology and immunohistochemistry.
Likewise, interferon-alpha has not been clearly implicated with transformation.
Rac1 has been implicated in transformation and metastasis [ 25, 42, 43].
In the setting of cellular transformation, EMT is also implicated in cancer metastasis.
Alterations in PKC isoenzyme expression have been implicated in transformation events in a number of cell types [ 13].
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CEO of Professional Science Editing for Scientists @ prosciediting.com