Exact(4)
Analytical relations are derived to relate strain tensors and tangent stiffness moduli in the nominal and healing configurations for each postulated transformation hypothesis (i.e. strain, elastic strain energy, and power equivalence hypotheses).
Here, we sought to test the 'in situ transformation' hypothesis and investigate the details of this spontaneous lateral plasmid transfer.
The transformation hypothesis was incorporated in the 'effector cell hypothesis'.
The late destructive phase of RA, typically characterized by pannus formation, osteoclast activation and secretion of tissue-destructive enzymes, is considered mainly T-cell independent as it seems to be driven by an 'autonomous' fibroblast-like synoviocyte population, as suggested by the transformation hypothesis.
Similar(56)
Although it is possible to understand this population in the context of the activation-transformation hypothesis (Stern et al., 2006), it is also possible that it emerges de novo within the primitive streak as a population that has never adopted a neural plate identity.
More specifically, we will first focus on a version of the "State-Vector Model" including bystander-induced apoptosis of initiated cells, which was successfully fitted to in vitro data on neoplastic transformation supporting the hypothesis of a protective bystander effect mediated by apoptosis.
Overall, the discovery of KLF6/Klf6 down-regulation in two different models of MYC/Myc-driven cell transformation supports the hypothesis that c-MYC germline overexpression could act as a risk factor for prostate cancer by converging on a molecular mechanism such as the functional inactivation of the KLF6 gene or gene product.
There are many modeling formalisms for systems biology that have been developed for the purpose of transformation of structural hypotheses into interpretable and executable models [ 1, 2].
The results are consistent with the hypothesis that transformation plasticity is the mechanism by which shape change occurs in the chemically banded steel.
To be more precise, the acquisition of common knowledge, the investigation of problems, desires and expectations of a group of individuals, and the evaluation of their appreciation of a hypothesis for transformation produces different outcomes if one finds oneself within a true planning process, and these hypotheses can actually be carried out.
Subsequent analysis by confocal microscopy revealed a four-fold increase in the number of contiguous fluorescent hyphae (see Figure 2a "21d" and b), in keeping with the hypothesis that transformation mainly occurs via stable integration rather than through the incorporation of extra-chromosomal elements.
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