Sentence examples for transformation downstream from inspiring English sources

These observations provide evidence that AREG-mediated activation of endogenous EGFR is required for full transformation downstream of YAP.

Indeed, STAT3 tyrosine phosphorylation and consequent transcriptional activation was shown to be required for cell transformation downstream of several oncogenes, the prototype being v-Src [ 6- 8].

Thus, STAT3 exerts a central role in mediating tumoural transformation downstream of many different oncogenes and growth factors, via both its canonical transcriptional functions and its non-canonical, non-nuclear activities.

Although the relation of C3G and human cancer is controversial, an increase in C3G expression is observed in human small cell carcinoma [ 197], and a Crk-C3G-Rap1 pathway leading to B-RAF and Erk activation is involved in transformation downstream of Ret in papillary thyroid carcinoma [ 124].

Specific mechanisms of T cell transformation downstream of TLX1 involve the repression of the TCR α enhanceosome activity, the blockage of TCR α rearrangement, and downregulation of mitotic control genes, which induces the loss of the mitotic checkpoint in nontransformed preleukemic thymocytes [ 29, 30].

We have documented a significant phenotypic decrease in size-at-smolt transformation (downstream migration), size-at-first spawning and a change in the maturation reaction norms in a brown trout population following a change in size-selectivity of an obstacle to migration.

In addition, Src family signalling is thought to be important in the transformation process downstream of ErbB2, through regulation of the cytoskeletal changes that accompany malignant transformation [ 25].

Taken together, these data reveal the absolute requirement of the transcription factors Stat3 and Stat5 for the initial transformation event downstream of v-Abl and Bcr/Ablp210.

This suggests a role for FEF in eye-centered visual-to-motor transformations, with other spatial transformations implemented downstream.

Palm oil extraction is the central production process of the commodity chain around which it is possible to integrate the two other main processes: oil palm cultivation at the upstream end of the chain and industrial transformation at the downstream end.

Finally, Cyclin D1 is necessary to effect transformation of cells downstream of specific oncogenic stimuli [30].