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Specifically in breast cancer, altered levels of various homeobox genes are directly associated with cellular transformation, disruption of the cell cycle, apoptosis, and progression to a metastatic phenotype [ 3- 7].
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We need positive transformation not disruption.
There's only one part of Australia's political system that I'm confident is going to be able to drive this significant transformation, this disruption to things we've become so used to, in a manner that is consistent with our national values of fairness and opportunity – and that is the labour movement.
During periods of transformation and disruption, such as we are witnessing today, exemplified by the emergence of big science and the advent of the terabyte age, the basic signifiers are under siege and in a state of flux, amenable to change.
But most support an outcome preserving the wide-open Internet that birthed our current era of innovation, transformation and disruption.
The large size of the N. attenuata genome may have contributed to our failure to detect side-effects of transformation; gene disruption might be a rare event in a large background of non-coding DNA.
EWS oncogenic fusions may contribute to malignant transformation through disruption of RNA splicing, mediated by YB-1 [ 50 ].
LMP1 is expressed in EBV-associated lymphoma and is essential for B-cell transformation and disruption of cellular signal transduction.
TLS and EWS fusion proteins may contribute to malignant transformation through disruption of RNA splicing, mediated by TLS and EWS-binding proteins, such as YB-1 [ 50].
PDCD4 binding to eIF4A is required for its ability to inhibit translation and transformation as disruption of eIF4A binding to PDCD4 abolishes its effect on both [ 26].
CTPE cells become resistant to apoptosis during malignant transformation, and disruption of the JNK pathway and Bcl-2 overexpression play important roles in this resistance.
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