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This study provides additional mechanistic detail to arsenic-induced cellular transformation beginning with the analysis of histone posttranslation modifications.
The onset and progression of EH generated within this model recapitulate a clinically relevant, pathological transformation, beginning with disordered proliferation developing to simple EH, advancing to atypical EH, and then progressing to precancerous stages, all following a chronologic manner.
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The transformation begins there".
The transformation began amid failure.
"When did that transformation begin?
Once in the brine, the transformation begins.
"World transformation begins with self-transformation," he advises.
Transformation begins with a voice, one that the hearer distrusts.
-- Mark Frost tells a stirring version of how that transformation began.
In some ways, Portland is where his transformation began.
The transformation began in earnest with the 1990 World Cup.
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