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Relationships between morphological measures and weeks of gestation were also explored by linear regression with log transformation as appropriate.
Paired t-tests were performed with data normalized where required using either a log10 or reciprocal transformation as appropriate for the skew in the data.
The primary analyses will involve intention-to-treat comparisons between the two groups for the primary outcomes, with transformation as appropriate after examination of distributions, and adjusted for stratification variables.
The mean change will be compared between countries and arms using analysis of variance techniques, perhaps after transformation of the proportions to the arcsine or logit or logarithmic transformation as appropriate.
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Continuous variables showing a skewed distribution were transformed wherever possible using log, square root, or inverse square root transformations, as appropriate.
The distributions of the response variables were checked for normality and transformations were performed as appropriate.
All other analyses reported met the assumptions of the statistical procedures used, following transformations as appropriate.
Normalising transformations will be applied as appropriate.
Log transformation was performed for positively skewed variables, as appropriate.
The distributions of continuous variables were assessed for normality, and transformations of skewed variables were used in the analysis as appropriate.
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