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Mutations (e.g. deletions, fusions) that affect the integrity of transcription factors by altering their DNA-binding specificity and/or capacity to interact with cofactors can transform these proteins into potent oncogenes.
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The researchers were able to show that proteins within the ESCRT-III complex work in stages where one protein assembles into spirals while other proteins transform these spirals further into tighter corkscrew-shaped helices, which then bend the cellular membrane prior to it forming into a vesicle.
Specific processing is required to transform these proproteins into biologically active proteins [1].
However cells manage to produce and operate these molecules by using indexes, e.g. proteins that bind and transform these molecules.
MAFFT v7 was used to perform multiple-sequence alignment for each group of single-copy orthologous genes with default parameters, and transform the protein sequence alignments into nucleotide sequence alignments52.
Rapid writing of open reading frames (ORFs) for expressed proteins could transform protein engineering and production for protein design, synthetic biology, and structural analysis.
Deletion of the NRD in AtDREB2A transforms the protein to a constitutively active form [ 39].
They both contain chemicals that, under the right conditions, transform original proteins into something new.
Such alterations, which they describe "as a major concern," may transform harmless proteins into a dangerous ones.
But by looking at each protein as if it were a spherical cow with sticky patches, Charbonneau said scientists could learn more about the standard set of interactions that transform proteins from a liquid solution into crystals.
This motif can transform non-related proteins into substrates, and identifies >300 new putative CAPN3 targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com