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They defined the mapping between source XML data formats and archetype fields, and employed an XSLT script to transform data from sources to a common EHR under the given archetype constraints.
Knowing the typical ways to transform data.
Significance testing of distributions of FPKM values was performed using a two-sample Wilcoxon rank sum test, and for normally distributed log2 transformed data, t-tests were employed.
This analysis first employs phylogenetic transformation [ 23] and the transformed data are used to estimate a multivariate evolutionary rate parameter based on the Euclidean distance between each species and the origin of the phylogeny separately for the groups under study.
Core probe sets on the Human Exon 1.0 ST array were processed using the RMA16 algorithm (Affymetrix, Santa Clara, CA, USA) that employs quantile normalisation of log2 transformed data.
A general linear model was employed for repeated measures analysis of log10 transformed data using Dunnett's test with 95% confidence to counteract for multiple comparisons.
Therefore, only the dendrogram for the transformed data is depicted here to save space, transformed data being commonly employed in this type of analysis (Fig. 1).
We then employ a random forest machine-learning algorithm on the transformed data, and find 43 genes consistently associated with IPD across three geographically distinct WGS data sets of pneumococcal carriage isolates.
After applying the transformation, the model was refitted and the residual plots were employed to ascertain that the regression model was appropriate for the transformed data.
If the transformed data did not follow normal distribution, the traits were analyzed by a nonparametric mapping method employed in MapQTL5 [43].
Note that these data are transformed data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com