Pharmasset did not have a single major drug on the market, but the company had developed a drug called sofosbuvir, which promised to do for hepatitis C what protease inhibitors did for H.I.V. in the mid-nineties: transform a hard-to-treat illness into an easily managed disease.
He's unexpectedly found himself leading a unique effort to transform a region hit hard by globalization into an Internet-fueled center for locally-grown organic food.
The EU is finding it hard to transform a bunch of national rail monopolies into a pan-European market in which operators compete across borders.
Some sort of slowing was inevitable and welcome, but as we all know it is hard to transform a fast-growing economy into a moderately-growing one without triggering some sort of crash.
Gross's way out is through a tried and true method, voluminous reading, and while it is hard to transform a litany of books into inspired text, Gross somehow manages to do so.
This season is so much more effective that it's practically a master class in how tweaks can transform a series — and in how hard it is to judge a sitcom early on.
The previous works have characterized the glass transition behavior of lignin, where it transforms from a hard or glass-like state into a rubbery or viscous state upon heating (Ko et al. 2015).
SoHo, the Lower Manhattan neighborhood so named because it is south of Houston Street, has in the past four decades been transformed from a hard-bitten haven for artists into a magnet for such luxury retailers as Prada and Chanel.
By the end of the decade, the sound made its trip across the Atlantic Ocean, where it was consumed, copied, and transformed into a harder, brasher style of music, labeled "brostep" by both fans and critics.
This renovation transformed a "cramped, crowded, hard-used... building into a magisterial seat of government," Gugliotta observes in his meticulously detailed history.
The high-carbon surface transforms into a hard, brittle martensitic structure, while the lower-carbon interior transforms into a tougher, softer structure.
