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Often that column is derived by following a database relationship from each group member, but in some cases the column is derived from a combination of multiple database relationships plus computation that yields some meaningful biological relationship (e.g. the multiple queries needed to transform a gene set into the set of metabolic pathways in which the gene products catalyse reactions).
Based on observations pointing to NAD vertices of a gene tree as indicating potentially misplaced genes, we developed a polynomial-time algorithm for inferring the minimum number of leaf-removals required to transform a gene tree into an MD-tree, i.e. a tree with no NAD vertices.
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This is why most tumors develop only following two causative hits: firstly a mutation that transform a cellular gene in an oncogene, and secondly, a mutation that inactivate a tumor suppressor [41].
This distance metric designates minimum number of inversion operations necessary to transform an initial gene permutation into a target one.
Since then, investigators have been picking the gene apart in an effort to understand the mutations that could transform a healthy, vital gene into the cause of a fatal illness.
Instead of adding β-glucosidase, one may transform a β-glucosidase gene into the host.
Just before Thanksgiving, the President's Council of Advisors on Science and Technology warned the White House directly that it is no longer difficult to imagine how somebody might, simply by editing a gene, transform a common virus into a biological weapon.
Briefly, PathoLogic was used to convert the L. monocytogenes 10403S genome file in a GenBank format into a PGDB by transforming gene and gene product descriptions into a PGDB representation.
The stepwise accumulation of genetic alterations in oncogenes and tumor suppressor genes will transform a normal cell and finally leads to carcinogenesis (Farber, 1984).
Three dimensional principal component analysis (PCA) was accessed for both different cohorts based on the methylation proportion of 10 studied genes to transform a number of possibly correlated variables into a smaller number of uncorrelated variables.
Electrocompetent L. lactis cells were transformed with a Gene Pulser XCell (Bio-Rad Laboratories, HerCAles, CA, U.S.A).
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