DOI: http://dx.doi.org/10.7554/eLife.00757.013 To test for effects on induction of a T-dependent antibody response, EBI2-deficient or control mice were given transfers of wild-type HEL-specific Hy10 B cells and then immunized with HEL-SRBC.
Thus, in view of intense viremia that occurs in RVF, serial transfer of wild virus by needle is a recognized hazard of vaccinating livestock during outbreaks (29 ).
While the transfer of wild type CD4+ T cells into T-bet−/− × RAG2−/− doubly deficient mice was found to partially restore insulin resistance, indicating an important role for CD4+ T cells, complete restoration was not observed.
The transfer of wild type TReg to Rag1−/− mice lacking mature T and B cells caused abrogation of lung inflammation, accompanied by increased apoptosis of alveolar neutrophils and macrophage efferocytosis, together with reduced pro-inflammatory cytokines and doubling of TGF-β levels.
Kopf et al. recently showed, in a model of autoimmune myocarditis, that mice deficient in IL-1 receptor-1 were resistant to disease induction, but that this resistance could be overcome by the transfer of wild type DCs pulsed with autoantigen, since IL-1 signaling of the DCs now induced IL-12 production and effective autoantigen presentation [ 12].
As livestock vaccines are commonly sold in multidose vials and are administered with automatic syringes with intermittent needle changes, vaccine may inadvertently be given to viremic livestock, with the potential for serial transfer of wild RVFV to other animals or to humans through needle-stick injuries.
The transfer of wild-type BMMCs could completely rescue the impaired reproductive phenotype.
Thus, transfer of wild-type Axin might offer a possible approach for gene therapy of oesophageal SCC.
Similar adoptive transfer of wild-type DCs had no effect on pancreas pathology of the host mice.
Adoptive transfer of wild-type immune cells into immune-incompetent mice restored HPV-positive tumor clearance with cisplatin therapy [ 69].
