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In each case, the value corresponding to the horizontally transferred sequence was noted.
The origin of transferred sequence was identified correctly in only 69 of 116 cases (59.5%).
A recent HGT event can be detected more easily than ancient ones, because sequence similarity between donor and the transferred sequence will decrease and base composition of transferred sequence will ameliorate to the recipient genome after the fixation [ 15].
This paper nicely shows rare somatic recombinant molecules that include between 36 bp to 120 bp of transferred sequence.
Most horizontally transferred genes go through the process of amelioration, the adjustment of the transferred sequence to the base composition and codon usage of the resident genome.
Viewed in this light, HGT is an asymmetric duplication because only the removal of the transferred sequence in the receiving species (the target copy) returns the system to its original state.
Similar(51)
Additionally, there was no apparent clustering pattern when transferred sequences were aligned to the circular genome of the Wolbachia endosymbiont of B. malayi (Fig. 1).
However, alien genes tend to be purified by selection and to be transient residents in the host genome due to the natural barriers to oppose the invasiveness of transferred sequences [36], [39].
Genes from low G+C regions not containing phage gene BLAST hits were then compared against the NCBI non-redundant database to confirm the absence of horizontally transferred sequences.
The variability in the strain of the top BLAST hit and the average percent identity to that hit suggests that transfer(s) either came from a species that is not represented in public databases and/or that the transferred sequences have mutated over time with respect to their parent gene.
Another 42% of the "recently" transferred sequences had unknown functions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com