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To date, the main advantage of the hCMEC/D3 cell line is that it represents a stable, easily grown and transferable population of human microvascular CEC that stably maintains a normal BBB phenotype.
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Compared with AFLP markers, STS markers are more valuable in marker-assisted selection (MAS) and more transferable between populations.
Since the first GWAS discoveries, numerous studies have examined whether the identified obesity-susceptibility loci are transferable across populations of other ancestry.
Linkage maps of kelp have been tentatively constructed (e.g., [ 64]); unfortunately the markers on these maps are mainly AFLPs which are not transferable among populations.
Recent evidence suggests that tagSNPs are transferable across populations of similar race/ethnicity without loss of information (Ke et al. 2004).
A few marker systems have been used in kelp [ 63- 69]; however they were either low throughput or not transferable among populations or number limited.
Differences in the genetic architecture and LD structure of different ancestries can help to narrow down the locus in order to pinpoint the causal gene or variants, at least for loci that are transferable across populations of different ancestry.
First, INDELs are more easily transferable between populations compared to microsatellites and applicable for a wide range of species for which expressed sequence tag collections for in silico INDEL identification are available.
However, the results are transferable to populations and contexts similar in characteristics as the data have been carefully collected and analyzed, with the main aim of understanding instead of seeking explanations [ 33].
The above studies have shown that tagSNPs are transferable to other population and HapMap SNPs demonstrate concordance with the closely related population.
It is unclear whether genetic variants and loci identified from European ancestry populations are transferable to non-European populations, and if ancestry-specific genetic loci are present.
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