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Using the publicly available data from the latest GWAS meta-analysis for BMI from the GIANT consortium [ 19], we illustrate how the BMI-associated loci identified in East Asian ancestry populations, of which the SNP-to-SNP transferability to European ancestry populations was doubtful, do show evidence of transferability when the whole locus is examined.
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The second is that the choice enabled the assessment of whether adjustment increases transferability when value sets are comparable, and whether adjustment is feasible when the value sets differ at both high and low values, and if adjustment is feasible when high values are comparable between value sets but low values are not.
Another aspect of transferability, when clinical laboratory results are used, concerns differences in analytical performance of measuring instruments.
However, when the transferability was considered for each subclass, the performance of the test set that corresponded to the data used to train the model was noticeably better.
Thus, SNP-to-SNP comparison allows confirmation of the transferability of a locus when the index SNP shows association in other ancestries.
Cross-species transferability is considered successful when the EST-SSR is functional (i.e. one or two PCR product are present) and it is polymorphic (i.e. two or more alleles in the genera) [ 7]. Almost all the loci fulfilled the aforementioned criteria (75%%).
Differences in LD levels between breeding populations hamper the transferability of marker effects from one breeding population to another, even when the linkage phases are identical.
Consequently, we only tested the transferability of models for those of our clusters with a season-independent model, when the model explained more than half of the variance of the cluster mean.
The greater this transferability, the broader the programme.
Regarding transferability, the present study was performed in the context of the Swedish legislation requiring that donors be identifiable if the donor offspring should wish to search for them when the offspring reach maturity.
Some reports suggest that SSR markers have higher transferability rates when used between closely related species [ 6, 22, 55].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com