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What does a particular transferability score really say?
Some of the checklists generate a summary transferability score, assigning either equal importance to each issue [ 2] or weighting the importance of each issue [ 3].
11 Based on the responses for each item in the checklist, Boulenger generated an overall transferability score based on the assumption that each item or factor contributes equal weight to the overall score.
The mean percentage transferability information score for the full checklist was 66.9% ± 13.6%, and the results obtained for the sub-checklist (68.8% ± 15.1%) were very similar to the full-checklist, suggesting a high correlation between overall study quality and a good transferability score.
However, due to the complexities of identifying appropriate weights for each of the noncritical factors, it is still uncertain whether the assessment and calculation of an overall transferability score or index will be practical or useful for transferability considerations in the future.
Assigning a transferability score of 1 to the recently acquired genes and 0 to the resident genes in the E. coli genome, we found, consistent to the result in figure 2 B, a significantly negative correlation between transferability and expression level (Spearman's rank correlation ρ = −0.283, P = 0.0001; rank biserial correlation r rb = −0.499, P = 0.0001; table 1).
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The disadvantage is that the transferability scores are difficult to interpret.
The potential relationship between the transferability information score and the characteristics of the study (multi-country vs single-country) was explored using χ test; however, no statistically significant differences were found.
Cross species transferability was scored positively only when sharp band(s) were present.
DArT markers, however, offer substantial advantages over PCR-based markersuchch as independence form gel electrophoresis and sequence information, transferability, reproducibility, automated scoring and high throughput, which allow obtaining more reliable results in a more cost effective way.
ρ2 measures the transferability of predicted risk scores between two centers using the same VMC signature and ρ3 measures the transferability of predicted risk scores using MCC modeled with different signatures.
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