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These are the first transfer vectors to use a neo/gusA selection system.
Efficient myocardial gene transfer in the intact adult heart is difficult using conventional transfer vectors.
The boundary element method (BEM) is then applied to find the frequency-dependent modal acoustic transfer vectors (MATVs).
Initial attempts at gene therapy of these hemoglobinopathies have proved unsuccessful due to limitations of available gene transfer vectors.
Gene transfer vectors based on adeno-associated virus (AAV) are showing exciting therapeutic promise in early phase clinical trials.
Imaging of transduced cells and tissues is valuable in developing gene transfer vectors and evaluating gene therapy efficacy.
In addition, IRESs are also promising biotechnological tools to design gene transfer vectors able to co-express several therapeutic molecules.
Gene transfer vectors based on adeno-associated virus (AAV) are now widely used in the field of gene therapy.
One potential solution is implanting tissue-engineering constructs loaded with gene transfer vectors such as viruses for localized transgene delivery.
A better understanding of integration will aid in the design of safer and more effective gene transfer vectors.
Replication-defective vectors based on murine oncoretroviruses were the first gene transfer vectors to be used in successful gene therapies.
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