Conversely, CRISPRs can prevent horizontal gene transfer by repression of plasmids and thus may contribute to the formation of independent bacterial lineages, similar to other prokaryotic repressive mechanisms of plasmids [ 66].
One explanation for the transient nature of the splicing repression is transfer of the memory traces from the hippocampus to other brain networks for memory consolidation.
Using mouse model systems of human metastatic ILC, evidence is provided that ILC cells are prone to relief of Kaiso-dependent transcriptional repression upon transfer to anchorage independence.
The P-type T4SS of the PRF 81 megaplasmid was similar to conjugation machineries present in R. etli CFN42 pSym, S. meliloti 1021 pSymA, and A. tumefaciens C58 pAt plasmid [ 117], and included the regulatory gene rctA that is required for repression of conjugative transfer [ 118].
Much work remains to establish the mechanistic bases of the links between these effects and the repression of horizontally transferred genes, pathogenicity islands, and pervasive antisense and noncoding transcription.
Because exosomes released from DKO-1 cells contain abundant levels of miR-100, increased Luc repression is consistent with transfer of additional copies of miR-100.
Watch out for repression and transference.
Having three perfect sites rather than one would actually underestimate the strength of Luc repression due to miR-100 transfer.
More recently, a strong repression of telomerase was observed following transfer of human chromosome 3 into human breast cancer cells (Cuthbert et al, 1999).
They are known to influence the evolution of an organism e.g. through gene activation and inactivation, repression, deletions, rearrangements, recombinations, and gene transfers [ 1].
