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(73) It can be shown that, for the transport of non-amphiphilic chemicals through a symmetrical bilayer, PC = l i /2, where l i is the water-to-bilayer transfer rate parameter.
K p,0 reflects the baseline value of the pth transfer rate parameter at the time of the first dose of study medication, g p (t) and h p (q ij ) the time and drug effects on the transfer rate, t the continuous time and q ij the exposure measurement for the jth observation of ith subject.
Some attempts at description of the concentration−lipophilicity profiles were based on the use of a reduced time τ (where τ = lo t, with lo being the transfer rate parameter for the membrane−water direction and t being time; see Figure 7 in section ).
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Reasonable values for all mass transfer rate parameters were estimated based on the available surface science and membrane permeation literature.
The obtained mass transfer rate parameters provide a good fit to the experimental data also for no-flow conditions.
The porosity estimate was updated during the estimation of mass transfer rate parameters to account for the effect of pore diffusion on bulk flow.
An efficient objective function for the estimation of the mass transfer rate parameters was devised to avoid the local minimum and to improve the convergence to the desired solution.
When fitted to data for toluene, a multiregion mass transfer model was found to predict the experimental data satisfactorily for the other components without adjustment of the mass transfer rate parameters.
The obtained mass transfer rate parameters provide a reasonable fit to the experimental data, predicting the cleanup time and the general saturation and concentration pattern quite well but failing to predict the concentration curves at every individual sampling port.
The rapid scan spectrometer was used to determine the heterogeneous electron transfer rate parameters for the oxidation of Biliverdin in DMF by single potential step thin layer spectroelectrochemical techniques and yielded an average formal heterogeneous electron transfer rate constant K0′s,h = 2.45 (±0.12) × 10−4 cm s−1, electrochemical transfer coefficient α = 0.694 ± 0.008.
Inter-individual variability was assessed for the six transfer rate parameters.
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