The G→A nucleotide change causing the sperm-transfer phenotype in sy671 was found at nucleotide 346 using the E and F primer set.
Orthology helps to transfer phenotype information based on genotypes.
As characterized by Goodell et al [17], SP from primary AML patients not only has the ability to transfer leukemic phenotypes in NOD-SCID mouse model, but more importantly, these cells have the capacity for rapid efflux of anti-leukemic drugs such as daunorubicin and mitoxantrone.
Subsequently we transferred this respiratory phenotype in the presence of up to 50 g/L glucose to a yeast strain, V5 hxt1-7Δ, in which only HXT1-7 had been deleted.
Importantly, LV/ACDase gene transfer resulted in an intermediate phenotype in Asah1P361R/P361R mice compared to controls as highlighted by enhanced growth, prolonged survival, reduced leukocyte counts, and lower ceramide levels.
If these regulatory B cells retain a stable phenotype in patients, transfer of this subset may be beneficial, in addition to depleting B cells that function only to present antigen to T cells.
TregPMA cells expressed regulatory markers and proved to ameliorate the disease phenotype in murine CD45RB transfer colitis model.
The functionality of the TregPMA cells has been demonstrated in vivo by their potential to ameliorate the disease phenotype in a CD45RB transfer colitis mouse model.
In this manuscript, we show that EVs can mediate the transfer of both malignant and non-malignant cellular phenotype in colon cells.
Likewise, the penicillin-induced obesity phenotype in the mouse could be transferred by fecal transplantation (Cox et al., 2014).
TIDC phenotype in RAG1−/− mice was not significantly affected by the transfer of purified CD8+ T cells or CD4+CD25+ Treg one day before tumor inoculation (data not shown).
