Sentence examples for transfer of tau from inspiring English sources

Thus, it appears that the presence of amyloid accelerates the interneuronal transfer of tau.

Nevertheless, the transfer of Tau proteins from neuron to neuron has not been conclusively demonstrated.

These observations suggest that the presence of amyloid pathology enhances the trans-synaptic transfer of tau in vivo.

Recent evidence suggests that the progression of Tau pathology could be based on the cell-to-cell transfer of Tau aggregates via axonally connected neurons.

The present study represents the first clear demonstration of the in vivo transfer of Tau proteins between anatomically connected neurons at distant brain (d > 10 mm).

The hierarchical pathways of NFD in tauopathies might be associated with the trans-synaptic transfer of Tau pathology, as recently suggested in vivo[ 20, 21].

Finally, from data obtained from our in vivo model, one may argue that only a few secondary neurons displayed AT8-immunoreactivity and that it remains unclear whether this effect reflects the transfer of hyperphosphorylated Tau or a subsequent V5-Tau hyperphosphorylation occurring in secondary neurons.

Such differential behaviour between the two Tau species also supports the in vivo specific trans-synaptic transfer of soluble Tau species rather than aggregates, as suggested using WT V5-Tau.

However, in two lines of transgenic mice overexpressing a single isoform of mutant tau (P301L), known to cause fronto-temporal dementia, inter-neuronal transfer of mutant tau appears to occur before any marked neurodegeneration [ 5, 6].

Altogether, these analyses strongly suggest that the spatio-temporal transfer of WT Tau is progressing through neural networks.

In these models, Tau diffusion was consistently observed in close vicinity to the expression region, and no definite evidence of a direct cell-to-cell transfer of pathological Tau proteins was provided.