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Conversely, it is accepted that the NMDA receptor is crucial in the transfer of nociceptive information in the spinal cord, specifically between the first and second nociceptive projection neurons [ 48].
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Nerves in the nasal cavity are responsible for the transfer of chemosensory (chemicals and odors), nociceptive (pain), thermoceptive (temperature), and mechanoceptive (touch) information to the CNS.
This would allow the transfer of Aβ input to structures integrating nociceptive information such as the parabrachial area, providing a mechanism by which touch turns into pain.
The nociceptive flexion reflex can be used as a tool to investigate modulation of nociceptive transmission at spinal level.
Yet, a quantitative description of nociceptive and non-nociceptive responses in the human spinal cord, compared with random signal fluctuations in resting state data, is still lacking.
In addition, none of the previous studies investigated the entire spectrum of nociceptive modalities.
Lateral atlantoaxial (LAA) joints are established sources of nociceptive input in chronic whiplash associated disorder (WAD).
The nociceptive activity of wild type hproNGF was determined at first, since nothing is known on the sensitization of nociceptive pathways by proNGF.
Nociceptive threshold tests are standard models of nociceptive pain in laboratory animals [ 1].
Its mechanisms differ in part from those of nociceptive pain.
Enhanced synaptic efficiency of nociceptive networks may facilitate the perception of pain with little or no peripheral nociceptive input.
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