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Passive transfer of immune sera from LANAC immunized mice to non-immunized mice confers protection to challenge, indicating that non-neutralizing antibody is sufficient for protection.
To further confirm that IDLV.142T is able to direct the immune system toward the induction of immune tolerance to transgene antigens, we reconstituted immune-deficient recipients through the adoptive transfer of immune cells derived from either immunized (IDLV-treated) or tolerized (IDLV.142T-treated) mice (Fig. 6C).
Antifilarial antibodies have been reported to play an important role in protective immunity evidenced by studies where passive transfer of immune sera from resistant to naive animals showed reduced adult worm establishment [ 43].
Adoptive transfer of immune T cells also conferred protection in the challenge model whereas passive transfer of immune serum did not, indicating the critical role for T cell responses in control of this infection.
Knowingly or unknowingly, breeding for resistance has largely relied on the transfer of immune receptor recognition specificities between plant genotypes.
Passive transfer of immune sera to the VP proteins did not protect unvaccinated mice from lethal disease.
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Passive transfers of immune sera to patients have demonstrated that premunition is mediated by antibodies as IgG from clinically immune individuals can control parasite density and disease symptoms in recipients [3] [6].
The transfer of immunity from parents to offspring (trans-generational immune priming (TGIP)) boosts offspring immune defence and parasite resistance.
We have investigated the transfer of milk immune cells and examined the result of transfer once the recipients were adult.
Colostrum from cattle is very high in IgG as it is the main route of transfer of the immune proteins to the calf, which can directly absorb these large proteins to the blood within the first 24 hours [31].
Moreover, transfer of EBOV immune serum in rodent and nonhuman primate models provided inconsistent results.
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