Sentence examples for transfer of hepatic from inspiring English sources
MTP plays an important role in VLDL assembly by mediating the transfer of hepatic lipids to nascent apoB [ 27].
In conclusion, liver-directed TFEB gene transfer resulted in correction of hepatic disease by increased SERPINA1 polymer degradation mediated by enhancement of autophagy flux.
Hepatocyte TFEB gene transfer resulted in dramatic reduction of hepatic ATZ, liver apoptosis and fibrosis, which are key features of alpha-1-anti-trypsin deficiency.
Free retinol can be transferred to hepatic stellate cells for storage.
In our current report, we demonstrate that AAV8-mediated gene transfer with hepatic expression of wtApoA-I or ApoA-IM results in plasma levels of ApoA-I that are sufficient to significantly slow the development of atherosclerosis in mice.
While other factors such as TG export may influence hepatic lipid accumulation, we did not find a significant difference in the expression of hepatic microsomal triglyceride transfer protein (Mttp) between the groups although ApoB expression in the wild-type livers was significantly reduced when challenged with the HFD, a response not seen in the Tsc1−/− mice (Figure 9B).
The efficacy of hepatic TFEB gene transfer was evaluated in the PiZ mouse model, a transgenic mouse that expresses the mutant human SERPINA1 gene under the control of its endogenous regulatory elements and recapitulates the features of human liver disease.
On the other hand, gene transfer and hepatic overexpression of SR-BI reduced atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse [10].
Amino transferases, aspartate transaminase (AST) and alanine transaminase (ALT) catalyse amino transfer reactions and are used as markers of hepatic injury [ 43].
In the present study, we have investigated whether hepatic gene transfer of TFEB promotes clearance of hepatotoxic ATZ.
Gene transfer of IGF-1 to the hepatic tissues is proven to be able to improve liver histology and functions in established liver cirrhotic rats [ 27].
