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It facilitates the transfer of extracellular molecules into cells activated through ultrasound driven microbubbles.
Sandgren et al. demonstrated that LL-37 facilitates transfer of extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and endocytosis [25].
Notably, a common form of HGT known as "natural transformation" involves transfer of extracellular DNA 4, 5.
Transfer of extracellular miRNAs by mutant DKO-1 cells promotes target repression in wild-type DKs-8 cells.
In the last two decades, a third mechanism for intercellular communication has emerged that involves intercellular transfer of extracellular vesicles (EVs) [ 1].
DOI: http://dx.doi.org/10.7554/eLife.07197.021 10.7554/eLiFigure97.022 Figure 6 figure supplement 3. Transfer of extracellular miRNAs by mutant DKO-1 cells promotes target repression in wild-type DKs-8 cells.
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No clear evidence that this happens has been shown in previous studies, although a potential transfer mechanisms of extracellular signal peptides across the outer membrane of Gram-negative bacteria has recently been reported [23].
31– 33 In addition, Yoshida et al reported that in vivo gene transfer of an extracellular domain of PDGFR-β reduced BLM-induced pulmonary fibrosis.
In parallel, there appear to have been sporadic transfers of large extracellular multidomain versions as well as intracellular versions fused to DNA-binding HTH domains to certain euryarchaeal lineages.
In the recent years, a lot of reports came up suggesting that major cardiovascular and metabolic pathologies like atherogenesis, heart failure, or diabetes are highly influenced by transfer of microRNAs via extracellular vesicles leading to altered protein expression and phenotypes of recipient cells.
The existence of two additional pcc gene clusters in G. sulfurreducens PCA suggests multiple, parallel pathways for transferring electrons across the outer membrane, which signifies the importance of extracellular electron transfer in the physiology of this microorganism.
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