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In T cells, the transfer of endogenous FasL from effector cells can result in apoptosis in the receiving cell.
We confirmed this hypothesis by demonstrating that genistein increases PKA activity and that genistein-increased eNOS protein expression and NO production in HAEC are completely blocked by adenoviral transfer of endogenous PKA inhibitor gene, which is highly specific and efficient, because it completely blocked PKA activity, whereas heat-inactivated AdPKI had no significant effect on PKA activity.
The passive transfer of endogenous Tregs from early disease stage mSOD1 mice into ALS mice, again without ex vivo activation, was further shown to have substantially greater immunomodulatory benefit compared with ALS mice receiving wild-type or mSOD1 CD4+ T lymphocytes.
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These technical advances enabled the transfer of entire endogenous membrane proteins into emulsified artificial liposomes and the retrieval of target receptors utilizing immobilized peptides.
Therefore, BPA-GA may be transferred across the placenta into the fetus by placental transporters that mediate transfer of essential endogenous physiological estrogenic compounds.
To determine how ActOVA DCs were unable to take advantage of peptide transfer to endogenous cells for T cell activation, we compared the stability of surface MHC-bound peptides on ActOVA DCs to their stability on peptide-DCs.
Evidence for transfer and seeding of endogenous α-syn was presented 24.
To the best of our knowledge, this is the first in vivo study that provides the quantitative data on the transfer of exogenous or endogenous labels from BMSCs to host macrophages that are found in the inflamed tissues.
However, chemical inhibition of protein kinase A (PKA) or adenoviral transfer of the specific endogenous PKA inhibitor gene completely abolished PKA activity and genistein-stimulated eNOS expression and NO production.
In a porcine model of acquired lymphedema, animals were treated with BioBridge scaffolds, alone or in conjunction with autologous lymph node transfer as a source of endogenous lymphatic growth factor.
Moreover, in the case of informational constraints (more specifically, spouses who do not know each others' preferences well) or the impossibility to make binding and costlessly enforceable agreements on the transfer of (in our case endogenous) resources, the non-cooperative setting is a useful benchmark.
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