Exact(2)
Finally, the FGF-1 IRES is very attractive to develop multicistronic expression cassettes for gene transfer in mouse muscle.
In addition, MCP-1 and -3 have shown antitumour activity by chemokine gene transfer in mouse models (Hoshino et al, 1995; Fioretti et al, 1998).
Similar(57)
A commonly cited example of this differential resource transfer in mice is the paternally expressed gene Igf2 (insulin-like growth factor 2), which enhances fetal growth and placental nutrient transport capacity, and the maternally expressed Igf2 receptor (Igf2r), which degrades excessive Igf2 protein.
The study also evaluated the effect of the micromanipulation procedure on the outcome of somatic cell nuclear transfer in mice.
We recently demonstrated that IL-23 gene transfer in mice rapidly induced synovial inflammation and osteoclastogenesis in the absence of T cells [ 5].
For instance, codon optimization of the murine FVII cDNA resulted in complete loss of transgene expression following AAV-mediated gene transfer in mice (data not shown).
We have evaluated the antitumor effect of combining IL-12 with CD gene transfer in mice bearing renal cell carcinoma (Renca) tumors.
Following embryo transfer in mice, the rate of fetal survival almost doubles after exposure to BMP-15 or GDF-9, but no differences could be detected in implantation rates (Yeo et al., 2008).
Tanigawa et al. found that hepatic CETP gene transfer in mice stimulated the transport of cholesterol from peritoneal macrophages to the liver, followed by its elimination as bile acids.
Meanwhile, CETP gene transfer in mice was found to increase RCT from peripheral macrophages in vivo, and human plasma with high CETP activity was shown to have a greater capacity to remove cholesterol from cultured cells than plasma with low activity.
Loci containing gamma-retroviral gene transfer vectors in mouse hematopoietic precursor cells showed small but significant repositioning of the integration loci towards the nuclear interior.
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