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Gas transfer impairment, in combination with spirometry, was likely helpful in more accurately identifying intrinsic RVD.
Interestingly, prohibitin deficiency has been linked to electron transfer impairment at complex I [64,65] and several links between ETC complexes and prohibitins have been described [66,67].
Factors identified as important in the estimation of RVD in this group of miners included BMI, gas transfer impairment and spirometric acceptability criteria.
Similarly, four chemically different chaperone molecules (4-PBA, glycerol, TMAO and TUDCA) also protected against dye transfer impairment, whereas butyrate, a control for 4-PBA, did not.
Other factors identified as important considerations in the estimation of restrictive ventilatory defect included increased BMI and gas transfer impairment in a relatively smaller proportion of those with spirometric restriction.
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These characteristics include being a very old female, having chronic dizziness, poor perceived health (bad and very bad), presence of depression symptoms, visual deficits, osteoarthritis and transfers impairment.
Data regarding patients' strength, spasticity, and transfer skills impairment were also collected.
We examined geriatric factors including dependence in ambulation, dependence in transferring and cognitive impairment.
Severe urinary incontinence was more common at baseline in older adults with dependence in ambulation and transferring and cognitive impairment.
Specifically we found that older age, dependence on others for ambulation or transferring and cognitive impairment were all independent predictors for urinary incontinence.
Based on the above we hypothesized that in patients with SSc the respiratory drive, as measured by P0.1, V'E/P0.1 and mouth occlusion pressures to CO2 rebreathing, may better relate to the magnitude of reported dyspnea than the severity of gas transfer or lung volume impairment as measured by PFTs.
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