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Maximizing the average power generated from such systems requires the transducer current to be regulated using a bi-directional power electronic converter.
If instead the transducer current is regulated using a converter capable of single-directional power-flow, then these parasitic losses can be reduced significantly.
No resting transducer current occurred at any potential.
Also, a small resting transducer current was evident at negative potentials that increased at positive potentials.
When the same voltage step protocol was applied to homozygous av3J/av3J OHCs the transducer current was absent or small at all but the most positive potentials (Fig. 6E), where clear current responses could be seen.
In three mutant OHCs, bundle displacements were measured and it was found that a bundle displacement of 57±16 nm (in the negative direction) was required to elicit a transducer current at −84 mV.
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Furthermore, transducer currents can be recorded in response to hair bundle movements.
In the homozygous av3J/av3J and v2J/v2J OHCs, small transducer currents were observed at negative holding potentials, but in response to force stimuli directed away from the kinocilium, whilst larger transducer currents could be elicited at positive potentials.
In the av6J/av6J mutants, transducer currents could be elicited over the range of membrane potentials tested (Fig. 6B).
Three v2J/v2J OHCs tested with force steps responded with transducer currents to both negative (largest) and positive (smaller) stimuli.
Figure 6F shows the averaged current-voltage curves for the peak-to-peak transducer currents of five +/av3J and five av3J/av3J OHCs.
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