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Transdermal oestradiol is a potential alternative to LHRHa.
Longitudinal studies (grade B methodology) have shown that transdermal oestradiol induces fewer migraines than oral conjugated oestrogens and that HRT taken continuously induces fewer migraine attacks than discontinuous treatment.
HRT included oral oestrogens, transdermal oestradiol, oestradiol implants, and tibolone, and use was classified as nonuse or ever use when there was no or any recorded use in the database, respectively.
Amenorrhoeic women (4 out of 6 women) were given hormone replacement in the form of transdermal oestradiol (Estraderm 100 TTS changed twice per week) and progesterone (Utrogestan 300 mg per day from day 15 to 28) for 3 months before the PTX-Vit E treatment.
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Overall, migraine is not a contraindication for HRT, but if aggravation of migraine is observed, notably with aura on HRT, alternatives should be discussed with the patient, including a change to a transdermal form, a reduction of the oestradiol dose, or stopping HRT completely.
Conversely, Martin et al. [17] in a randomized, placebo-controlled study on 21 patients, treated with GnRH-a and with GnRH-a associated with estrogens, demonstrated a modest preventive benefit only in the group treated with GnRH-a (goserelin 3.6 mg implant) associated with a transdermal patch containing 100 μg of oestradiol-17β.
Only one study used any transdermal administration, comparing transdermal 17- β-diethyl-oestradiol administered as a cream with oral Stilboestrol (Steg et al, 1983).
– (levonorgesterel and oestradiol) without taking any antidepressants.
§ 524.1448 Mirtazapine transdermal ointment.
Last year alone, sales of transdermal testosterone doubled.
However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane.
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