First, existence of stable polycistronic transcripts; however, to date there are not descriptions of mature polycistronic transcripts in Leishmania.
Given the presence of the spliced leader sequence on all dinoflagellate nuclear encoded transcripts investigated to date, and its implication of post-transcriptional control of gene expression, it was somewhat surprising to see the early response of gene transcripts in Cluster 5 of both the N- and P- addition experiments, which were dominated by PPR proteins.
More than 75% of human genes have structural isoforms of transcripts, but to date few studies have been conducted to verify the alternative splicing systematically.
All nuclear encoded gene transcripts studied to date possess a 5' trans-spliced leader (SL) sequence suggestive, based on the trypanosome model, of post-transcriptional regulation.
Data from this microarray analysis revealed 1,668 Bvg-regulated genes, which dramatically increases the number of Bvg-regulated transcripts identified to date.
The propensity of LHR to generate a number of alternatively spliced mRNA transcripts has to date not been shown to equate to the production of an extended and functionally diverse family of LHR variants.
Using a bioinformatics approach, Liu and colleagues (2007) found Alu repeats in the TMPRSS2 and ERG breakpoint regions and that the distribution of these repeats correlates with the structure of the multiple TMPRSS2-ERG fusion transcripts identified to date [ 22].
However, the presence of both H2d and H2a in all gnathostome coe/ ebf transcripts characterised to date both indicates that, in this case, exon-skipping is highly counter-selected.
As indicated elsewhere (Gao et al, 2002), this 40 kbp component of EBV DNA includes among its genes those encoding CST/BART transcripts, which to date have been identified in all EBV-positive tumours (reviewed in Smith, 2001), and an oncogene, BARF1, with functional homology to human colony-stimulating factor (CSF) receptor (Strockbine et al, 1998), a product of the proto-oncogene, c- fms.
Indeed, more than half of the transcripts (9/16) studied to date in A. acetabulum are localized to one end or the other of the unicell, most often to its apex [ 31- 33].
