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Each step in gene transcription, including chromatin remodeling, activation and interactions between transcription factors, and transcriptional processing, appears to be elegantly orchestrated with complementary processes in other genes.
miRNAs are often present in gene clusters and it is generally believed that individual miRNAs are generated from common polycistronic transcript by post - transcriptional processing [ 51, 52].
Therefore, regulation of post - transcriptional processing may be a preferred mechanism, instead of transcription control in case of miRNAs present in clusters.
RNA editing is another post transcriptional processing mechanism.
In addition we show that miRNA levels can be regulated at post - transcriptional processing stage.
However, it is not clear if PA4406 sRNA arises due to transcriptional processing or if it has its own promoter.
Similar(51)
In turn, these ncRNAs have similarly been implicated in the regulation of chromatin architecture and dynamics, transcription, post-transcriptional processing, and RNA editing and trafficking.
The transcription, post-transcriptional processing, and assembly of rRNA occurs in the nucleolus, aided by small nucleolar RNA (snoRNA) molecules, some of which are derived from spliced introns from messenger RNAs encoding genes related to ribosomal function.
Understanding the multi-layered complexity of gene regulation is central to this goal, from the process of chromatin remodeling to transcription initiation, post-transcriptional processing and modulation, and protein modification and interaction.
Deregulation of miRNAs in cancer can be caused by chromosomal deletions, amplifications and translocations; by hypermethylation of CpG islands; and by regulation of transcription and post-transcriptional processing [1], [2], [23].
Many long transcripts undergo post-transcriptional processing that generates short RNA sequence fragments.
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