These results suggest that despite the incomplete reflection of the effects of miRNAs at the transcription level (issue 4) and the presence of other transcriptional regulatory mechanisms (issue 5), it is still possible to systematically analyze the effects of miRNAs on their targets using RNA-seq data.
From this perspective, the regulation of mtDNA transcription is an issue of major importance.
Analysis consisted of coding transcriptions into particular issues or 'themes' related to the 3 areas of patients' information search prior to attending the website, the problems in comprehensibility and usability of the information, and how patients evaluated the new website.
However excessive levels of transcription often result in DNA damage as detailed by Aguilera and colleagues in this issue.
14 15 The H@N system also highlighted issues with transcription of information: Each junior made notes on loose paper when calls were received, and these were sometimes very brief because pressing clinical matters curtailed conversations.
This article is part of a Special Issue entitled: Transcription by Odd Pols.
The characterization of the genomic elements which govern the spatial and temporal tuning of gene transcription is a key issue in genomic biology, providing with a better understanding of the cell regulatory networks and the functional landscape of the genome [1].
The genes identified will be invaluable in further studies examining the processes of oocyte maturation in addition to addressing the existing conflicting issue of transcription during meiotic maturation.
Clinical issue The transcription factor Myc is a central regulator of many cellular processes, including growth, proliferation, apoptosis, metabolism and differentiation, and its expression is deregulated in a wide variety of human cancers.
This dataset provides a unique reference resource for studies concerned with the molecular mechanisms controlling oocyte meiotic maturation in cattle, addresses the existing conflicting issue of transcription during meiotic maturation and contributes to the global goal of improving assisted reproductive technology.
