Exact(29)
In addition, it has been shown that this allele functions by increasing the stability of the dzs10 transcript via a post transcriptional mechanism [ 9] and is controlled by a locus called dzr1, which is not genetically linked to dzs10[ 9- 11].
The expanded GAA triplet-repeat sequence results in deficiency of FXN transcript via at least two mechanisms: deficient transcriptional elongation through the expanded repeat tract [3], [16], [17] and epigenetic silencing [6] [8].
Pol II proofreads the nascent transcript via its intrinsic nuclease activity to maintain high transcriptional fidelity critical for cell growth and viability.
The DGE protocol generates a single read predominantly from the 5' end of the transcript via selective priming from the 3' end [11], providing a direct indication of transcription initiation.
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Similar(31)
AcuM, a transcriptional regulator of gluconeogenic genes, has recently been suggested to repress SreA and thereby induce HapX transcripts via transcriptional profiling experiments [ 75].
Focusing on APOE expression in temporal lobe clearly illustrates that, used together, RNA-Seq and Cufflinks can identify not only transcriptional regulation of a gene but also post-transcriptional regulation of primary transcripts via alternative splicing.
We validated the microarray findings by quantifying irg1, ifit3, and socs3 transcripts via quantitative reverse transcription PCR (qRT-PCR) using several of the original RNA samples as templates.
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We show that Spoonbill interacts with toxic SCA8 transcripts via its KH domain and promotes its depletion.
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