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Transcript up- and down-regulation differed strongly between the tissues and showed sensitivity to the time of day (Fig. 1).
The podcast is up at TalkCrunch and embedded below, and we will have a transcript up shortly as well.
The clearest finding from our study was that the most over-expressed transcript (up to x70 fold) was associated with an innate-effector AMP.
The entire ChIP-Enrich analyze list is included in Additional file 4 To illustrate by an alternative approach the position of FUS and EWS ChIP-seq peaks we next used a transcript based model in which each annotated transcript was analyzed for the presence of FUS, EWS, and Ac-H3K9 peaks within or in close distance to the transcript (up to 10 kb).
For each protein-coding transcript in C. elegans (total: 22,428), we extracted the region upstream of the ATG to the nearest protein-coding transcript, up to a maximum length of 700 bp and a minimum length of 100 bp (Genome version WS220).
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Since sez-6 is an activity-regulated mRNA transcript, up-regulated in neurons after pentylenetetrazole (PTZ) treatment [5], training mice in an enriched environment [6] and long-term potentiation induction [7], we wish to investigate whether or not Sez-6 is involved in the maturation and/or activity-regulated remodelling of retinal circuitry [8], [9].
ABCC10 transcript up-regulation has also been shown in salivary gland adenocarcinoma [21].
Our findings suggest that COX4I2 transcript up-regulation is a marker of hypoxia-induced mitochondrial plasticity.
One transcript up-regulated after 1 h is similar to Arabidopsis PFT1, a subunit of the Mediator complex.
Colon Cancer Associated Transcript 1 (CCAT1) is a unique transcript up-regulated in CC compared to normal human tissues [ 25].
By RT-PCR analysis a COL6A6 transcript up-regulation was detected in all samples (fold change ranging from 3.297 up to 171.254).
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