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Together, these results suggest that the absence of dmtA transcript results in a pronounced defect in early sexual development.
Based on previously published data, only mRNA transcribed from the Dnmt3L full form transcript results in functional protein [9].
The location of the 5' end of Mirg indicated that this truncated transcript results as result of processing of the exonic miR-485 precursor.
We contrasted the individual transcript results of this analysis with the first study to address the impact of aging on expression at the transcriptome level [11].
Similarly, alternative splicing of the late transcript results in production of the viral capsid proteins VP1, VP2, and VP3 all of which are important for completion of the viral lytic cycle and formation of viral particles.
Alternative splicing of the WT1 transcript results in the inclusion or skipping of 9 nucleotides in exon 9 that encode the amino acids Lysine-Threonine-Serine (KTS) that are consequently present or absent between the third and fourth zinc finger domains of the protein.
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Deletion of CBC results in a reduction in the recruitment of several splicing factors to the nascent transcript resulting in inhibition of co-transcriptional spliceosome assembly [ 86].
This allows discrimination of a wildtype transcript and a mutant, null transcript resulting from recombination.
Thus, the expression of long CAG repeats in the 3' UTR of the EGFP transcript resulted in decreased protein production.
Finally, we confirm that an endogenous transcript resulting from intronic promoter activity exists in embryonic and adult tissues and starts in the intronic, conserved region.
This suggests that the higher level of CD46-Cyt2 tresulting resulting from CD46 engagement in MS patients may influence their T cell responses.
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